The calcium-sensing receptor and related diseases
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چکیده
منابع مشابه
The calcium-sensing receptor and related diseases.
The calcium-sensing receptor (CASR) adjusts the extracellular calcium set point regulating PTH secretion and renal calcium excretion. The receptor is expressed in several tissues and is also involved in other cellular functions such as proliferation, differentiation and other hormonal secretion. High extracellular calcium levels activate the receptor resulting in modulation of several signaling...
متن کاملCalcium-sensing receptor and associated diseases.
The calcium-sensing receptor (CASR) is expressed in parathyroid hormone (PTH)-secreting cells of the parathyroid gland and cells lining the renal tubule. The activated CASR modulates intracellular signaling pathways altering PTH secretion and renal cation and water handling. Inherited abnormalities of the CASR gene give rise to a variety of disorders of mineral ion homeostasis. Heterozygous los...
متن کاملCalcium sensing receptor and heart diseases.
BACKGROUND Calcium ion is the first identified endogenous substance to function as both a first and second messenger via the stimulation of an extracellular calcium sensing receptor (CaR). CaR is a seven transmembrane G-protein-coupled receptor, which activates intracellular effectors, for example, it causes inositol phosphate (IP) accumulation to increase the release of intracellular calcium. ...
متن کاملDiseases associated with calcium-sensing receptor
The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. The diseases caused by an abnormality of the CaSR are genetically determined or are more rarely acquired. The genetic diseases consist of hyper- or hypocalcemia disorders. Hypercalcaemia disorders are related to inactivating mutations...
متن کاملThe calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport.
The transfer of calcium from mother to milk during lactation is poorly understood. In this report, we demonstrate that parathyroid hormone-related protein (PTHrP) production and calcium transport in mammary epithelial cells are regulated by extracellular calcium acting through the calcium-sensing receptor (CaR). The CaR becomes expressed on mammary epithelial cells at the transition from pregna...
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ژورنال
عنوان ژورنال: Arquivos Brasileiros de Endocrinologia & Metabologia
سال: 2006
ISSN: 0004-2730
DOI: 10.1590/s0004-27302006000400008